J. Settleman : rechercher sur Z-Library

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1

Epidermal growth factor receptor mutations in lung cancer

Sharma, Sreenath V., Bell, Daphne W., Settleman, Jeffrey, Haber, Daniel A.

Journal:

Nature Reviews Cancer

Année:

2007

Langue:

english

Fichier:

PDF, 441 KB

english, 2007

2

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

Singh, A, Settleman, J

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 603 KB

english, 2010

3

A Structure-Guided Approach to Creating Covalent FGFR Inhibitors

Wenjun Zhou, Wooyoung Hur, Ultan McDermott, Amit Dutt, Wa Xian, Scott B. Ficarro, Jianming Zhang, Sreenath V. Sharma, Joan Brugge, Matthew Meyerson, Jeffrey Settleman, Nathanael S. Gray

Journal:

Chemistry & Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2010

4

Factors underlying sensitivity of cancers to small-molecule kinase inhibitors

Jänne, Pasi A., Gray, Nathanael, Settleman, Jeff

Journal:

Nature Reviews Drug Discovery

Année:

2009

Langue:

english

Fichier:

PDF, 755 KB

english, 2009

5

GAP control: regulating the regulators of small GTPases

Andre Bernards, Jeffrey Settleman

Journal:

Trends in Cell Biology

Année:

2004

Langue:

english

Fichier:

PDF, 463 KB

english, 2004

6

p120-Catenin and p190RhoGAP Regulate Cell-Cell Adhesion by Coordinating Antagonism between Rac and Rho

Gregg A. Wildenberg, Michael R. Dohn, Robert H. Carnahan, Michael A. Davis, Nichole A. Lobdell, Jeffrey Settleman, Albert B. Reynolds

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 2.03 MB

english, 2006

7

The Rho GTPase and a Putative RhoGEF Mediate a Signaling Pathway for the Cell Shape Changes in Drosophila Gastrulation

Kathy Barrett, Maria Leptin, Jeffrey Settleman

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 706 KB

english, 1997

8

From Cancer Genomics to Precision Oncology—Tissue’s Still an Issue

Cohen, Robert L., Settleman, Jeff

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 415 KB

english, 2014

9

Communication in Drug Development: “Translating” Scientific Discovery

Settleman, Jeff, Cohen, Robert L.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 375 KB

english, 2016

10

Molecular Targeted Therapy of Lung Cancer: EGFR Mutations and Response to EGFR Inhibitors

HABER, D.A., BELL, D.W., SORDELLA, R., KWAK, E.L., GODIN-HEYMANN, N., SHARMA, S.V., LYNCH, T.J., SETTLEMAN, J.

Journal:

Cold Spring Harbor Symposia on Quantitative Biology

Année:

2005

Langue:

english

Fichier:

PDF, 1.65 MB

english, 2005

11

TORquing metabolic reprogramming in cancer cells

Pusapati, Raju, Settleman, Jeff

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 926 KB

english, 2016

12

Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis

David J. Riese II, Richard M. Gallo, Jeffrey Settleman

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 157 KB

english, 2007

13

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

Dora Dias-Santagata, Sara Akhavanfard, Serena S. David, Kathy Vernovsky, Georgiana Kuhlmann, Susan L. Boisvert, Hannah Stubbs, Ultan McDermott, Jeffrey Settleman, Eunice L. Kwak, Jeffrey W. Clark, Ste

Journal:

EMBO Molecular Medicine

Année:

2010

Langue:

english

Fichier:

PDF, 790 KB

english, 2010

14

Combinatorial treatment of non-small-cell lung cancers with gefitinib and Ad.mda-7 enhances apoptosis-induction and reverses resistance to a single therapy

Luni Emdad, Irina V. Lebedeva, Zao-Zhong Su, Pankaj Gupta, Devanand Sarkar, Jeffrey Settleman, Paul B. Fisher

Journal:

Journal of Cellular Physiology

Année:

2007

Langue:

english

Fichier:

PDF, 497 KB

english, 2007

15

Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with Tarceva

Pankaj Gupta, Luni Emdad, Irina V. Lebedeva, Devanand Sarkar, Paul Dent, David T. Curiel, Jeffrey Settleman, Paul B. Fisher

Journal:

Journal of Cellular Physiology

Année:

2008

Langue:

english

Fichier:

PDF, 351 KB

english, 2008

16

Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3

Chan-Young Jeon, Hee-Jun Kim, Hiroshi Morii, Nozomu Mori, Jeffrey Settleman, Jae-Yong Lee, Jaebong Kim, Sung-Chan Kim, Jae-Bong Park

Journal:

Journal of Cellular Physiology

Année:

2010

Langue:

english

Fichier:

PDF, 315 KB

english, 2010

17

Erratum: Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3

Chan-Young Jeon, Hee-Jun Kim, Hiroshi Morii, Nozomu Mori, Jeffrey Settleman, Jae-Yong Lee, Jaebong Kim, Sung-Chan Kim, Jae-Bong Park

Journal:

Journal of Cellular Physiology

Année:

2011

Langue:

english

Fichier:

PDF, 43 KB

english, 2011

18

Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase duringDrosophiladevelopment

Valerie Verdier, Guang-Chao-Chen, Jeffrey Settleman

Journal:

BMC Developmental Biology

Année:

2006

Langue:

english

Fichier:

PDF, 1.47 MB

english, 2006

19

p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation

Brouns, Madeleine R., Matheson, Stephen F., Settleman, Jeffrey

Journal:

Nature Cell Biology

Année:

2001

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2001

20

Association between GTPase activators for Rho and Ras families

Settleman, Jeffrey, Albright, Charles F., Foster, Lauren C., Weinberg, Robert A.

Journal:

Année:

1992

Fichier:

PDF, 250 KB

1992

21

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

Zhang, Xian-Feng, Settleman, Jeffrey, Kyriakis, John, Takeuchi-Suzuki, Erika, Elledge, Stephen J., Marshall, Mark S., Bruder, Joseph T., Rapp, Ulf R., Avruch, Joseph

Journal:

Année:

1993

Fichier:

PDF, 758 KB

1993

22

Cancer: Drivers and passengers

Haber, Daniel A., Settleman, Jeff

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 357 KB

english, 2007

23

10.1038/71390

Settleman, Jeffrey

Journal:

Nature Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 123 KB

english, 2000

24

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR

Bell, Daphne W, Gore, Ira, Okimoto, Ross A, Godin-Heymann, Nadia, Sordella, Raffaella, Mulloy, Roseann, Sharma, Sreenath V, Brannigan, Brian W, Mohapatra, Gayatry, Settleman, Jeff

Journal:

Nature Genetics

Année:

2005

Langue:

english

Fichier:

PDF, 113 KB

english, 2005

25

Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents

Sharma, Sreenath V., Haber, Daniel A., Settleman, Jeff

Journal:

Nature Reviews Cancer

Année:

2010

Langue:

english

Fichier:

PDF, 508 KB

english, 2010

26

E1B 55K sequesters WT1 along with p53 within a cytoplasmic body in adenovirus-transformed kidney cells

Maheswaran, Shyamala, Englert, Christoph, Lee, Sean Bong, Ezzel, Robert M, Settleman, Jeffrey, Haber, Daniel A

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 1.20 MB

english, 1998

27

RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion

Zrihan-Licht, Sheila, Fu, Yigong, Settleman, Jeffrey, Schinkmann, Karin, Shaw, Leslie, Keydar, Iafa, Avraham, Shalom, Avraham, Hava

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 495 KB

english, 2000

28

Emerging concepts in tumor progression and therapy

Marie Classon, Jeff Settleman

Journal:

Seminars in Cancer Biology

Année:

2000

Langue:

english

Fichier:

PDF, 121 KB

english, 2000

29

Integrated HPV 1 genomes in a human keratinocyte cell line can be transactivated by a SV40/BPV1 recombinant virus which expresses BPV1 E2 proteins

Adrian Partow, Roger A. Grand, Paul Biggs, Settleman Jeffrey, Daniel Dimaio, Phillip H. Gallimore

Journal:

Année:

1990

Langue:

english

Fichier:

PDF, 2.40 MB

english, 1990

30

The complexity of targeting EGFR signalling in cancer: From expression to turnover

Sinto Sebastian, Jeffrey Settleman, Stephan J. Reshkin, Amalia Azzariti, Antonia Bellizzi, Angelo Paradiso

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Année:

2006

Langue:

english

Fichier:

PDF, 654 KB

english, 2006

31

Exploiting the balance between life and death: Targeted cancer therapy and “oncogenic shock”

Sreenath V. Sharma, Jeff Settleman

Journal:

Biochemical Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 322 KB

english, 2010

32

Interaction of the EGFR inhibitors gefitinib, vandetanib, pelitinib and neratinib with the ABCG2 multidrug transporter: Implications for the emergence and reversal of cancer drug resistance

Csilla Hegedüs, Krisztina Truta-Feles, Géza Antalffy, György Várady, Katalin Német, Csilla Özvegy-Laczka, György Kéri, László Őrfi, Gergely Szakács, Jeffrey Settleman, András Váradi, Balázs Sarkadi

Journal:

Biochemical Pharmacology

Année:

2012

Langue:

english

Fichier:

PDF, 905 KB

english, 2012

33

A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes

Sreenath V. Sharma, Patrycja Gajowniczek, Inna P. Way, Diana Y. Lee, Jane Jiang, Yuki Yuza, Marie Classon, Daniel A. Haber, Jeffrey Settleman

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2006

34

Drugging the Bad “AKT-TOR” to Overcome TKI-Resistant Lung Cancer

Jeffrey Settleman, Jonathan M. Kurie

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 78 KB

english, 2007

35

A Therapeutic Opportunity in Melanoma: ErbB4 Makes a Mark on Skin

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 57 KB

english, 2009

36

A Gene Expression Signature Associated with “K-Ras Addiction” Reveals Regulators of EMT and Tumor Cell Survival

Anurag Singh, Patricia Greninger, Daniel Rhodes, Louise Koopman, Sheila Violette, Nabeel Bardeesy, Jeff Settleman

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2009

37

A Common Signaling Cascade May Underlie “Addiction” to the Src, BCR-ABL, and EGF Receptor Oncogenes

Sreenath V. Sharma, Patrycja Gajowniczek, Inna Way, Diana Lee, Jane Jiang, Yuki Yuza, Marie Classon, Daniel A. Haber, Jeffrey Settleman

Journal:

Année:

2009

Fichier:

PDF, 256 KB

2009

38

Neuregulin-1-Mediated Autocrine Signaling Underlies Sensitivity to HER2 Kinase Inhibitors in a Subset of Human Cancers

Timothy R. Wilson, Diana Y. Lee, Leanne Berry, David S. Shames, Jeff Settleman

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2011

39

Rho-LIM Kinase Signaling Regulates Ecdysone-Induced Gene Expression and Morphogenesis during Drosophila Metamorphosis

Guang-Chao Chen, Patrycja Gajowniczek, Jeffrey Settleman

Journal:

Current Biology

Année:

2004

Langue:

english

Fichier:

PDF, 537 KB

english, 2004

40

Adhesion-Dependent Regulation of p190RhoGAP in the Developing Brain by the Abl-Related Gene Tyrosine Kinase

Samuel E Hernández, Jeffrey Settleman, Anthony J Koleske

Journal:

Current Biology

Année:

2004

Langue:

english

Fichier:

PDF, 425 KB

english, 2004

41

The Drosophila ATM Ortholog, dATM, Mediates the Response to Ionizing Radiation and to Spontaneous DNA Damage during Development

Young-Han Song, Gladys Mirey, Martha Betson, Daniel A Haber, Jeffrey Settleman

Journal:

Current Biology

Année:

2004

Langue:

english

Fichier:

PDF, 404 KB

english, 2004

42

Coordination of Rho and Rac GTPase Function via p190B RhoGAP

Rodrigo I. Bustos, Marie-Annick Forget, Jeffrey E. Settleman, Steen H. Hansen

Journal:

Current Biology

Année:

2008

Langue:

english

Fichier:

PDF, 478 KB

english, 2008

43

Cancer: miRNA Addiction — Depending On Life's Little Things

David Dornan, Jeff Settleman

Journal:

Current Biology

Année:

2010

Langue:

english

Fichier:

PDF, 44 KB

english, 2010

44

Oncogene addiction

Jeffrey Settleman

Journal:

Current Biology

Année:

2012

Langue:

english

Fichier:

PDF, 53 KB

english, 2012

45

P190A RhoGAP is required for mammary gland development

B.M. Heckman-Stoddard, T. Vargo-Gogola, M.P. Herrick, A.P. Visbal, M.T. Lewis, J. Settleman, J.M. Rosen

Journal:

Developmental Biology

Année:

2011

Langue:

english

Fichier:

PDF, 3.00 MB

english, 2011

46

ErbBs in lung cancer

Sreenath V. Sharma, Jeffrey Settleman

Journal:

Experimental Cell Research

Année:

2009

Langue:

english

Fichier:

PDF, 984 KB

english, 2009

47

Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization

Sylvie Vincent, Jeffrey Settleman

Journal:

European Journal of Cell Biology

Année:

1999

Langue:

english

Fichier:

PDF, 3.29 MB

english, 1999

48

Rnd Proteins Function as RhoA Antagonists by Activating p190 RhoGAP

Krister Wennerberg, Marie-Annick Forget, Shawn M Ellerbroek, William T Arthur, Keith Burridge, Jeffrey Settleman, Channing J Der, Steen H Hansen

Journal:

Current Biology

Année:

2003

Langue:

english

Fichier:

PDF, 576 KB

english, 2003

49

Rho family GTPases: more than simple switches

Marc Symons, Jeff Settleman

Journal:

Trends in Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 102 KB

english, 2000

50

Cell Culture Modeling of Genotype-Directed Sensitivity to Selective Kinase Inhibitors: Targeting the Anaplastic Lymphoma Kinase (ALK)

Journal:

Seminars in Oncology

Année:

2009

Langue:

english

Fichier:

PDF, 162 KB

english, 2009